HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(Tert-butyldimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one → 1-(4-Hydroxy-cyclohexyl)-3-(3-methyl-benzofuran-2-ylmethyl)-pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(Tert-butyldimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one | HCID 59299475 | — |
| Reactant | 2-(Bromomethyl)-3-methyl-1-benzofuran | HCID 59557398 | — |
| Product | 1-(4-Hydroxy-cyclohexyl)-3-(3-methyl-benzofuran-2-ylmethyl)-pyrrolidin-2-one | HCID 11659891 | 54% |
Reaction Steps
Using the procedure to synthesize Example 3 and using reagents 1-[4-(tert-butyldimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one (500 mg, 1.68 mmol) and 2-bromomethyl-3-methyl-benzofuran (567 g, 2.52 mmol) afford the title compound as a tan powder (295 mg, 54%): Mass spectrum (apci) m/z=328.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834194B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-720a6fe720a94c4da0fb9d08db0d5696 |
| Source note | uspto-grants-2010_11 |