反应详情

温度

0 °C

Dissolve 3-(3-chloro-6-methoxy-benzo[b]thiophen-2-ylmethyl)-1-cyclohexylpyrrolidin-2-one (1.122 g, 2.97 mmol) and 2-methyl-2 propene (0.5 mL) in dichloromethane (30 mL) and cool to 0° C. Slowly add boron tribromide (2.23 g, 8.91 mmol) and warm to room temperature. Stir for 1 hour and quench with ice. Extract with dichloromethane, dry with sodium sulfate, filter, and concentrate to give the title compound (1.121 g, 99%) as a light brown solid: Mass spectrum (apci) m/z=364.2 (M+H).

1. customquench with ice
2. extractionExtract with dichloromethane
3. dry with materialdry with sodium sulfate
4. filtrationfilter
5. concentrationconcentrate