HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → 4-[(1,3-Dioxoisoindolin-2-yl)methyl]-1-benzenesulfonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Benzylphthalimide | HCID 75059 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-[(1,3-Dioxoisoindolin-2-yl)methyl]-1-benzenesulfonyl Chloride | HCID 21084407 | — |
Reaction Steps
The compound (330 mg) obtained in Example 24-1 was dissolved in chloroform and then added with chlorosulfuric acid (manufactured by Kishida Chemical Co., Ltd.) (0.177 ml) under ice-cooling. The solution was stirred at room temperature for 2 days, and then concentrated and dried. The resultant was gradually added with phosphorus pentachloride (300 mg) and then heated to 80° C., followed by stirring for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07833991B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-9cb180d787b140fd9f9875d4835ed969 |
| Source note | uspto-grants-2010_11 |