HCID 66941167, compound → HCID 66941790, compound

HRID 1173875Notes

Reaction equation

HRID 1173875 reaction equation
[C:1]([O:5][C:6](=[O:24])[N:7]([CH2:18][C:19]1[NH:20][CH:21]=[CH:22][N:23]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[C:1]([O:5][C:6](=[O:24])[N:7]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=1)[CH2:18][C:19]1[NH:23][CH:22]=[CH:21][N:20]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 66941167HCID 66941167, compound

Product 1

HCID 66941790HCID 66941790, compoundYield 78.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The compound (325 mg) obtained in Example 34-2 was dissolved in ethanol (15 ml) and then cooled with ice. The solution was carefully added with 10% palladium-carbon (Mitsuwa Chemicals Co., Ltd.) (300 mg), followed by stirring under a hydrogen atmosphere for 30 minutes. The solution was subjected to Celite filtration and the filtrate was then concentrated, thereby obtaining the subject compound (233 mg) as a pale-red white solid.

Workup

  1. temperaturecooled with ice
  2. filtrationThe solution was subjected to Celite filtration
  3. concentrationthe filtrate was then concentrated

Sources & evidence

ORD record
ord-4ad498fe4bfd44c9872c4e764e9a30ae
Source dataset
uspto-grants-2010_11
Patent number
US07833991B2

Reaction notes

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