反应详情

The compound (390 mg) obtained in Example 36-2 was dissolved by the addition of anhydrous methanol (20 ml), and the solution was added with imidazole-2-carboxaldehyde (453 mg) and sodium cyanoborohydride (341 mg), and adjusted to pH 5 by the addition of acetic acid (0.5 ml), followed by stirring for 18 hours. After completion of the reaction, the methanol was distilled off and the residue was then added with 1 mol/l sodium hydroxide (20 ml), followed by extraction with chloroform. The organic layer was washed with saturated saline solution and then dried with anhydrous magnesium sulfate. After that, the solvent was distilled off and the residue was then dried, thereby obtaining the subject compound (680 mg) as a white solid.

1. customAfter completion of the reaction
2. distillationthe methanol was distilled off
3. additionthe residue was then added with 1 mol/l sodium hydroxide (20 ml)
4. extractionfollowed by extraction with chloroform
5. washThe organic layer was washed with saturated saline solution
6. dry with materialdried with anhydrous magnesium sulfate
7. distillationAfter that, the solvent was distilled off
8. customthe residue was then dried