反应详情

The compound (44.3 mg) obtained in Example 1-4 was dissolved in methanol (1.0 ml) and then added with 6-methylpyridine-2-carboxaldehyde (20.7 mg) and sodium cyanoborohydride (10.7 mg). The solution was adjusted to about pH 5 with acetic acid and then stirred at room temperature for 15 hours. After completion of the reaction, the solvent was distilled off and the residue was then dissolved in chloroform, followed by washing with a 1 mol/l sodium hydroxide aqueous solution and saturated saline solution and drying with anhydrous sodium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/methanol/water), thereby obtaining the subject compound (9.9 mg) as a white solid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. dissolutionthe residue was then dissolved in chloroform
4. washby washing with a 1 mol/l sodium hydroxide aqueous solution and saturated saline solution
5. dry with materialdrying with anhydrous sodium sulfate
6. distillationThe solvent was distilled off
7. customthe residue was then purified through silica gel column chromatography (chloroform/methanol/water)