反应详情

The compound (1.4396 g) obtained in Example 24-2 was dissolved in anhydrous chloroform (28 ml) and then added with triethylamine (0.689 ml), followed by ice-cooling. Then, the solution was added with (4-aminobutyl)-carbamic acid t-butyl ester (852.9 mg) and stirred at room temperature for 2.5 hours. After the reaction, the solution was washed with water and dried with anhydrous magnesium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (1.4440 g) as a white solid.

1. temperaturecooling
2. customAfter the reaction
3. washthe solution was washed with water
4. dry with materialdried with anhydrous magnesium sulfate
5. distillationThe solvent was distilled off
6. customthe residue was then purified through silica gel column chromatography (chloroform/methanol)