反应详情

The compound (443 mg) obtained in Example 80-2 was dissolved in dichloromethane (9.0 ml) and added with manganese (IV) oxide (chemically treated product, manufactured by Wako Pure Chemical Industries, Ltd.) (873 mg), followed by stirring at room temperature for 5 hours. After completion of the reaction, the solution was filtrated through Celite and the filtrate was then concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (397 mg) as a brown solid.

1. customAfter completion of the reaction
2. filtrationthe solution was filtrated through Celite
3. concentrationthe filtrate was then concentrated under reduced pressure
4. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)