反应详情

温度

0 °C

Lithium aluminum hydride (138 mg) was suspended in THF (7 ml) and then cooled to 0° C. After that, a solution of the compound (361 mg) obtained in Example 125-3 in THF (7 ml) was dropped in the suspension, followed by stirring at 0° C. for 1 hour. After completion of the reaction, sodium sulfate decahydrate was continuously added to the solution until bubbling was stopped, and a 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate was generated. Solid matter was separated through filtration and the solvent was then distilled off from the filtrate under reduced pressure. The residue was dried under vacuum, thereby obtaining the subject compound (302 mg) as a pale-yellow viscous substance.

1. additionwas continuously added to the solution
2. customuntil bubbling
3. additiona 1 mol/l sodium hydroxide aqueous solution was then added to the mixture until a white precipitate
4. customSolid matter was separated through filtration
5. distillationthe solvent was then distilled off from the filtrate under reduced pressure
6. customThe residue was dried under vacuum