Hydrochloride methanol → 2-[2-(4-Dipropylamino-butyl)-1-methoxy-indan-5-ylmethyl]-isoindole-1,3-dione

Participants

Reaction Steps

The compound (253.9 mg) obtained in Example 127-11 was dissolved in methanol (10.2 ml), added with a 10% hydrogen chloride/methanol solution (5.08 ml), and stirred for 16 hours at room temperature. Then, the reaction solution was concentrated under reduced pressure and dried under vacuum. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (95.7 mg) as a yellow oily substance.

Provenance & Evidence