反应详情

The compound (45.0 mg) obtained in Example 127-13 was dissolved in methanol (2.25 ml) and added with 2-imidazole carboxaldehyde (19.5 mg) and trimethyl orthoformate (43.1 mg), followed by stirring at room temperature for 1 hour. Under ice-cooling, sodium borohydride (15.4 mg) was added to the solution, and the whole was stirred at room temperature for 30 minutes. The reaction solution was added with water and then subjected to separation/extraction with chloroform. The extract was washed with saturated saline solution, dried with anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (54.8 mg) as a yellow oily substance.

1. temperatureUnder ice-cooling
2. stirringthe whole was stirred at room temperature for 30 minutes
3. extractionsubjected to separation/extraction with chloroform
4. washThe extract was washed with saturated saline solution
5. dry with materialdried with anhydrous sodium sulfate
6. concentrationconcentrated under vacuum
7. customThe residue was purified through silica gel column chromatography (chloroform/methanol)