Sodium Trifluoroacetate → N-methoxymethyl-N-methylpyrrolidinium trifluoroacetate

HRID 1174042Notes

Reaction equation

HRID 1174042 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[Na+].[Cl-].[CH3:10][N+:11]1([CH2:16][O:17][CH3:18])[CH2:15][CH2:14][CH2:13][CH2:12]1>CO>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[CH3:18][O:17][CH2:16][N+:11]1([CH3:10])[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 517019Sodium TrifluoroacetateHCID 23116042N-methoxymethyl-N-methylpyrrolidinium chloride

Product 1

HCID 23116057N-methoxymethyl-N-methylpyrrolidinium trifluoroacetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 14.94 g quantity of sodium trifluoroacetate was dissolved in 100 g of methanol, and 18.20 g of N-methoxymethyl-N-methylpyrrolidinium chloride was added to the solution at room temperature. The mixture was stirred for 1 hour, concentrated in a vacuum and dried in a vacuum using a vacuum pump. The residue was dissolved in 500 ml of dichloromethane, followed by filtration with a membrane filter, concentration in a vacuum and drying, affording 26.52 g of a colorless liquid as the desired product.

Workup

  1. concentrationconcentrated in a vacuum
  2. customdried in a vacuum
  3. dissolutionThe residue was dissolved in 500 ml of dichloromethane
  4. filtrationfollowed by filtration with a membrane
  5. filtrationfilter
  6. concentrationconcentration in a vacuum
  7. customdrying

Sources & evidence

ORD record
ord-cb9af1f7f8c54fbdb42365bb52db8c27
Source dataset
uspto-grants-2010_11
Patent number
US07834197B2

Reaction notes

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