Cesium carbonate → HCID 77699942, compound

Participants

Reaction Steps

In a manner similar to the method described in example 1e, racemic (2′R, 3R,4′S)-2′-(2-allyloxy-5-iodo-phenyl)-6-chloro-4′-(3-chlorophenyl)-2,3-dihydro-2,6′-dioxo spiro[indole-3,3′-piperidine]-1-methoxyethyl trimethylsilane (5 g, 6.6 mmol) prepared in example 18c was reacted with bromo-acetic acid tert-butyl ester and cesium carbonate in N,N-dimethyl-formamide to give racemic (2′R, 3R, 4′S)-2′-(2-allyloxy-5-iodo-phenyl)-1′-[(tert-butoxycarbonyl)methyl]-6-chloro-4′-(3-chlorophenyl)-2,3-dihydro-2,6′-dioxo spiro[indole-3,3′-piperidine]-1-methoxyethyl trimethylsilane as a white foam (Yield: 2.8 g, 49%).

Provenance & Evidence