Toluene → 2,3,5-Triiodobenzoic acid

HRID 1174090Notes

Reaction equation

[CH:1]1[C:6]([I:7])=[C:5]([I:8])[C:4]([C:9]([OH:11])=[O:10])=[CH:3][C:2]=1[I:12].C1CCCCC1.C1(C)C=CC=CC=1>>[CH:1]1[C:6]([I:7])=[C:5]([I:8])[C:4]([C:9]([OH:11])=[O:10])=[CH:3][C:2]=1[I:12]

Participants

Reactant 2

HCID 1140Toluene

HCID 131728537TIBA cyclohexane

Product 1

HCID 69482,3,5-Triiodobenzoic acid

Procedure

13.7 mL of TIBA/cyclohexane solution (113 g/L) were mixed with 3.3 mL of MAO/toluene solution (Albemarle 30% wt/wt, d=0.92 g/mL, 15.6 mmol MAO) to obtain a MAO/TIBA molar ratio of 2:1. The solution was stirred for 1 h at room temperature and transferred into a 50 mL Schlenk flask containing A-1 (46.85 mg, 58.5 μmol). The final solution was diluted with 18.7 mL of cyclohexane. Final mixture concentration=70 gTOT/L and 1.313 gmetallocene/L; color=orange solution.

Sources & evidence

ORD record: ord-38a6e152b0694ec694c71967670332dc
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834205B2

Reaction notes

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