HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1174142Generated: October 30, 2026
Trifluoroacetic acid → (2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoic Acid
https://huagongshe.com/reaction/1174142
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl(2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoate | HCID 16037960 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S)-3,3-dimethyl-2-{3-[(6-methyl-2-pyridinyl)methyl]-2-oxo-1-imidazolidinyl}butanoic Acid | HCID 42626245 | 128.1% |
Reaction Steps
A solution containing the product from Example 10B (1.33 g, 3.68 mmol) in dichloromethane (20 mL) was treated with trifluoracetic acid (20 mL), stirred at 25° C. for 2 hours and concentrated. The residue was purified by reversed phase chromatography on a C18 column, eluting with 0-100% acetonitrile/water (0.1% TFA) to give the title compound (1.44 g, 94% yield) as the trifluoroacetic acid salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07834043B2 |
|---|
| Source dataset | uspto-grants-2010_11 |
|---|
| ORD ID | ord-62fc5f06f5dc4f2a89580d8112d769a0 |
|---|
| Source note | uspto-grants-2010_11 |
|---|
