反应详情

温度

25 °C

A solution of the product from Example 17A (8 g, 48 mmol) in dichloromethane (200 mL) was treated with electrolytic manganese dioxide (41.67 g, 0.48 mol). The mixture was stirred for 4 days at 25° C. and filtered through celite. The filtrate was concentrated under reduced pressure and the residue was purified by chromatography on silica gel eluting with 5% methanol in dichloromethane to give the title compound as a white solid (6.9 g, 87% yield).

1. filtrationfiltered through celite
2. concentrationThe filtrate was concentrated under reduced pressure
3. customthe residue was purified by chromatography on silica gel eluting with 5% methanol in dichloromethane