HCID 56593955, compound → HCID 67407889, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing the product from Example 23B (19.0 g, 40.1 mmol) in THF (48 mL) was treated dropwise with a solution of benzyl magnesium bromide (120 mL, 1 M in ether) at 0° C. The mixture was allowed to warm to 25° C. and was stirred for 16 hours. The reaction was cooled to 0° C. and quenched with 10% citric acid, followed by partitioning between ethyl acetate and water. The organic phase was washed with brine and dried over MgSO4, filtered and concentrated to give the crude product (23.2 g), which was used without further purification.

Provenance & Evidence