Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzyl succinimido carbonate | HCID 83172 | — |
| Reactant | HCID 56593958 | HCID 56593958 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 56594761 | HCID 56594761 | 70.1% |
Reaction Steps
A solution containing the product from Example 23F (6.1 g, 15.2 mmol) in THF (150 mL) was treated with N-(benzyloxycarbonyloxy)succinimide (3.4 g, 13.6 mmol) and N,N-diisopropylethylamine (3.3 mL, 19.0 mmol), stirred at 25° C. for 68 hours and concentrated. The residue was chromatographed on silica gel eluting with 33% ethyl acetate in chloroform and then with 10% methanol in chloroform to give the title compound (5.1 g, 63% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07834043B2 |
|---|
| Source dataset | uspto-grants-2010_11 |
|---|
| ORD ID | ord-956bfe160cc946da8d715ece7b93b9b3 |
|---|
| Source note | uspto-grants-2010_11 |
|---|
