HCID 67058748, compound → HCID 23159688, compound

Participants

Reaction Steps

1.6 g of β-(4-(4-propylcyclohexyl)cyclohexyl)-2-difluoromethyl-3-fluoro-4-ethoxy styrene obtained in Example 5 was dissolved in 25 ml of a mixed toluene-solmix solvent. A palladium carbon catalyst was added to the solution in a nitrogen atmosphere and a hydrogenation reaction was conducted at ambient temperature and pressure for 2 days. After the completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated under a reduced pressure and the residue was purified by silica gel column chromatography (eluent: heptane/toluene=9/1) to obtain 1-(2-difluoromethyl-3-fluoro-4-ethoxyphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane. This was further recrystallized twice from a heptane/ethanol mixed solvent to obtain pure 1-2-difluoromethyl-3-fluoro-4-ethoxyphenyl)-2-(4-(4-propylcyclohexyl)cyclohexyl)ethane. The compound showed a liquid crystal phase and the transition point was as described below.

Provenance & Evidence