Dimethyl Sulfoxide → HCID 59283806, compound

Participants

Reaction Steps

Methyl iodide 13.45 g (94.74 mmol) was dropwise added to a mixed solution of 8.41 g (31.58 mmol) of 13H-dibenzo[a,g]fluorene, 15.95 g (142.11 mmol) of potassium t-butoxide and 100 ml of dimethylsulfoxide at 20° C. in 20 minutes, and the solution was stirred for 8 hours. After left standing overnight, 13.45 g (94.74 mmol) of methyl iodide was further dropwise added and stirred for 11 hours. Water was dropwise added to the reaction mixture, and the solution was extracted twice with dichloromethane. After separating the solution, the organic phase was concentrated and refined by flash chromatograph (silica gel: hexane/dichloromethane=5/1) to obtain 4.66 g (yield: 50.1%) of 13,13-dimethyl-13H-dibenzo[a,g]fluorene.

Provenance & Evidence