Hydrochloric Acid → HCID 19427168, compound

Participants

Reaction Conditions

Reaction Steps

Diethyl 2,2-bis(2-cyanoethyl)malonate (2 g, 7.51 mmol) was added to TMAH (25% in water, 10.95 g, 30.04 mmol) at room temperature. The mixture was stirred for 24 hours, and was then cooled to 0° C. A mixture of 12M HCl (2.69 cm3, 32.1 mmol) and ice (3 g) was added and the mixture was extracted with CH2Cl2 (5×50 cm3). The extracts were evaporated under vacuum to give 2,2-bis(2-cyanoethyl)malonic acid (0.25 g, 15.8%) as a colourless very viscous oil (lit decomposed. 158° C.).

Provenance & Evidence