HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzoic acid → 4-(Aminomethyl)Benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzoic acid | HCID 12087 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Aminomethyl)Benzoic Acid | HCID 65526 | 84% |
Reaction Steps
A mixture of 4-cyano benzoic acid (500 g, 3.4 mol) and Raney Nickel (100 g) in methanol (5 L) was hydrogenated at a pressure of 10 kg for 16 h. The catalyst was removed by filtration, followed by the removal of the solvent under reduced pressure to afford 4-(aminomethyl)benzoic acid (430 g, 84%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838522B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-31f052c1aed34fb788e3e3dd05bcd70e |
| Source note | uspto-grants-2010_11 |