Diisopropylethylamine → tert-Butyl dibenzylcarbamate

Participants

Reaction Steps

To a mixture of N-(4-methoxycarbonylphenyl)benylamine (25 g, 0.098 mol) in CH2Cl2 (500 ml), was added diisopropyl ethylamine (38 g, 0.294 mol) and (BOC)2O (32 g, 0.147 mol). After stirring at r.t. for 5 h, the solvent was removed under reduce pressure. The crude product was then purified by chromatography using chloroform/methanol (9/1) to afford 4-methoxy carbonyl-[N-(BOC]-N-[benzyl]benzylamine (27 g, 78%) as a liquid.

Provenance & Evidence