HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Butene, 1-bromo-3-methyl- | HCID 70092 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 8-chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione | HCID 12617584 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine | HCID 22029722 | — |
Reaction Steps
5.87 mL of 1-bromo-3-methyl-2-butene is added to 10.56 g of 3-methyl-8-chloroxanthine and 17 mL of Hünig base in 100 mL of N,N-dimethylformamide. The reaction mixture is stirred for approximately 10 minutes at ambient temperature and then combined with 800 mL of water. The light-colored precipitate formed is suction filtered, washed with ethanol and diethyl ether and dried. Yield: 10.56 g (81% of theory); mass spectrum (ESI+): m/z=269, 271 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838529B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-6818f3ffc96e45e1b528163d03d08076 |
| Source note | uspto-grants-2010_11 |