Potassium Carbonate → tert-Butyl 5-[3-methyl-7-(3-methyl-but-2-enyl)-2,6-dioxo-1-(2-oxo-2-phenyl-ethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-cis-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

52 mg of 8-bromo-3-methyl-7-(3-methyl-but-2-enyl)-1-(2-oxo-2-phenyl-ethyl)-3,7-dihydro-purine-2,6-dione were dissolved in 1 ml of DMF, and 56 mg of tert-butyl cis-hexahydropyrrolo[3,4-c]pyrrole-2-carboxylate and 36.5 mg of potassium carbonate were added. The mixture was stirred at 90° C. for 5 hours, cooled and evaporated in a vacuum. The oily residue was purified by column chromatography (silica gel: mobile phase: methylene chloride: methanol=98:2).

Provenance & Evidence