Formamide → 3H,4H-thieno[3,2-d]pyrimidin-4-one

Participants

Reaction Conditions

Reaction Steps

Methyl-3-amino-2-thiophene carboxylate (510 mg, 3.24 mmol) was dissolved in formamide (20 ml) and heated at 170° C. 16h. The solvent was evaporated. The crude residue was then purified by flash chromatography on silica gel (2-4% MeOH/CH2Cl2 ) to afford the title compound 256 (157 mg, 32% yield). LRMS: 152.0 (Calc.); 152.9 (found).

Provenance & Evidence