反应详情

温度

55 °C

A mixture of ethyl 4-hydroxycyclohexanecarboxylate (2.0 g, 12 mmol) and hydrazine (1.5 g, 46 mmol) in methanol (20 mL) was stirred at 55° C. for 4 h and then cooled to room temperature (about 25° C.). After cooling, the solvent and excess hydrazine were removed by distillation under reduced pressure to provide a residue. The residue was co-evaporated with methanol (2×), and was then dried under high vacuum to provide the crude product 4-hydroxycyclohexanecarbohydrazide, which was used in the next synthesis step without further purification. LCMS: (M+H)+=155.2.

1. temperaturecooled to room temperature (about 25° C.)
2. temperatureAfter cooling
3. customthe solvent and excess hydrazine were removed by distillation under reduced pressure
4. customto provide a residue
5. customwas then dried under high vacuum