反应详情

温度

60 °C

A mixture of 4-(5-chloropyridin-2-yl)-4-hydroxycyclohexanecarboxylic acid ethyl ester (1.6 g) and sulfuric acid (5 ml) is heated at 60° C. for 15 minutes. After addition of water (0.4 ml) the mixture is again heated at 60° C. for 20 minutes. The cooled reaction mixture was diluted with water and washed with dichloromethane. The aqueous phase was adjusted to pH 7 with sodium bicarbonate solution and extracted with dichloromethane. The organic phase was dried over sodium sulfate and concentrated. The product with the molecular weight of 237.69 (C12H12ClNO2); MS (ESI): 238 (M+H+) was obtained in this way.

1. temperatureis again heated at 60° C. for 20 minutes
2. customThe cooled reaction mixture
3. washwashed with dichloromethane
4. extractionextracted with dichloromethane
5. dry with materialThe organic phase was dried over sodium sulfate
6. concentrationconcentrated
7. customMS (ESI): 238 (M+H+) was obtained in this way