Hydrochloric Acid → HCID 59557972, compound

Participants

Reaction Conditions

Reaction Steps

General Deprotection Procedure: A mixture of Compound B1 and 4 M HCl in dioxane was stirred at 40° C. overnight and concentrated. Excess HCl was evaporated with isopropyl alcohol provided Compound B2 as yellow solid (261 mg, 97%). 1H NMR (400 MHz CDCl3) δ (ppm): 10.9 (s, 1H), 8.96 (d, 2H), 8.17 (s, 1H), 7.84 (d, 4H), 4.40-4.37 (m, 1H), 3.25-3.22 (m, 2H), 3.16 (s, 3H), 3.01-2.93 (m, 2H), 2.04-2.01 (m, 2H), 1.88-1.78 (m, 2H). Exact mass calculated for C16H20N6O4S 392.13, LCMS (ESI) m/z 393.1 (M+H+, 100%).

Provenance & Evidence