HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzyloxy)-3-hydroxybenzonitrile → 4-Benzyloxy-3-hydroxybenzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzyloxy)-3-hydroxybenzonitrile | HCID 15453451 | — |
| Reactant | [3,5-Bis(benzyloxy)benzyl]amine hydrochloride | HCID 15505554 | — |
| Product | 4-Benzyloxy-3-hydroxybenzylamine | HCID 21904366 | 33% |
Reaction Steps
This compound was prepared according to procedure used in preparation of 3,5-dibenzyloxybenzylamine, starting from 4-benzyloxy-3-hydroxybenzonitrile. Yield was 33%. MP 122-125° C.; 1H NMR (DMSO-d6, 400 MHz) δ 8.9 (br, 1H), 7.44 (d, 2H, J=7.4 Hz), 7.35 (dd, 2H, J=7.0 and 7.7 Hz), 7.28 (dd, 1H, J=7.0 and 7.3), 6.85 (d, 1H, J=7.6 Hz), 6.77 (d, 1H, J=2.1 Hz), 6.61 (dd, 1H, J=7.4 and 2.2 Hz), 5.05 (s, 2H), 3.55 (s, 1H), 2.50 (br, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838542B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-3952f93ed1044d879b7719dfd67b89d5 |
| Source note | uspto-grants-2010_11 |