HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-amine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-butyl-1-(4-nitrophenyl)-1H-pyrazol-5-amine | HCID 1302360 | — |
| Reactant | Ethyl (4-hydrazinophenyl)acetate hydrochloride | HCID 21254104 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | ethyl[4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetate hydrochloride | HCID 86622904 | — |
Reaction Steps
The title compound was prepared in the same manner as described for 5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine, replacing 4-nitrophenylhydrazine with ethyl(4-hydrazinophenyl)acetate hydrochloride (11.98 g, 51.9 mmol). The title compound was obtained as a white solid (HCl salt, 11.95 g) in 68% yield. 1H-NMR (DMSO-d6) δ 7.52 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.1 Hz, 2H), 5.59 (s, 1H), 4.08 (q, J=7.1 Hz, 2H), 3.77 (s, 2H), 1.27 (s, 9H), 1.20 (t, J=7.1 Hz, 3H); MS LC-MS [M+H]+=302.3, RT=2.44 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838524B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-89d0dfe41b9c49f4a8efe94aab3bc4c1 |
| Source note | uspto-grants-2010_11 |