Cinnamic Acid → N-[2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-3-phenyl-acrylamide

Participants

Reaction Steps

Prepare according to Method B, using trans-cinnamic acid (96 mg, 0.648 mmol) and 2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine (162 mg, 0.618 mmol) to afford the title compound (31 mg, 13%). mass spectrum (m/e): 393.0 [M+H]. 1H NMR (400 MHz, DMSO-d6): δ 10.21 (s, 1H), 8.26 (d, 1H, J=1.3 Hz), 7.63 (d, 2H, J=7.0 Hz), 7.57 (d, 1H, J=15.7 Hz), 7.48-7.37 (m, 5H), 6.84 (d, 1H, J=15.8 Hz), 3.70 (dd, 1H, J =9.5, 7.0 Hz), 3.61 (m, 1H), 3.46 (m, 1H), 3.27 (m, 1H), 2.88 (m, 1H), 2.23-2.11 (m, 7H), 1.90 (m, 1H).

Provenance & Evidence