(2E)-3-(3-Fluorophenyl)-2-propenoic acid → N-[2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-3-(3-fluoro-phenyl)-acrylamide

Participants

Role	Name	HCID	Charge
Reactant	(2E)-3-(3-Fluorophenyl)-2-propenoic acid	HCID 1551219	—
Reactant	2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine	HCID 63231507	—
Product	N-[2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-3-(3-fluoro-phenyl)-acrylamide	HCID 68771353	16.9%

Reaction Steps

Prepare according to Method B, using trans-3-fluorocinnamic acid (98 mg, 0.590 mmol) and 2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine (162 mg, 0.618 mmol) to afford the title compound (41 mg, 16%). mass spectrum (m/e): 411.2 [M+H], 409.2 [M−H].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07838543B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-26c3186225c64975bb66f85578b8dfef
Source note	uspto-grants-2010_11