HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-phenylprop-2-enoic acid → N-[2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-2-methyl-3-phenyl-acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-phenylprop-2-enoic acid | HCID 14541 | — |
| Reactant | 2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine | HCID 63231507 | — |
| Product | N-[2-(3-Dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-2-methyl-3-phenyl-acrylamide | HCID 68773887 | 12.5% |
Reaction Steps
Prepare according to Method B, using α-methylcinnamic acid (99 mg, 0.610 mmol) and 2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine (162 mg, 0.618 mmol) to yield the title compound (31 mg, 12%). mass spectrum (m/e): 407.3 [M+H], 405.2 [M−H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838543B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-b7b09b6319774ceb8e77367715c08e81 |
| Source note | uspto-grants-2010_11 |