Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → Rac-2',4'-dichloro-biphenyl-4-carboxylic acid {2-[methyl-(1-methyl-pyrrolidin-3-ylmethyl)-amino]-benzooxazol-5-yl}-amide

HRID 1174929Notes

Reaction equation

HRID 1174929 reaction equation
[CH3:1][N:2]([CH2:13][CH:14]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15]1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:6]=2[N:7]=1.[Cl:20][C:21]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:22]=1[C:28]1[CH:33]=[CH:32][C:31]([C:34](O)=[O:35])=[CH:30][CH:29]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(Cl)Cl>[CH3:1][N:2]([CH2:13][CH:14]1[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15]1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([NH:12][C:34]([C:31]3[CH:32]=[CH:33][C:28]([C:22]4[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:21]=4[Cl:20])=[CH:29][CH:30]=3)=[O:35])=[CH:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 107542792',4'-Dichloro-biphenyl-4-carboxylic acidHCID 57771749Rac-n2-methyl-n2-(1-methyl-pyrrolidin-3-ylmethyl)-benzooxazole-2,5-diamine

Product 1

HCID 11533559Rac-2',4'-dichloro-biphenyl-4-carboxylic acid {2-[methyl-(1-methyl-pyrrolidin-3-ylmethyl)-amino]-benzooxazol-5-yl}-amideYield 45.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combine rac-N2-methyl-N2-(1-methyl-pyrrolidin-3-ylmethyl)-benzooxazole-2,5-diamine (0.040 g, 0.154 mmol), 2′,4′-dichloro-biphenyl-4-carboxylic acid (0.062 g, 0.230 mmol), HATU (0.058 g, 0.154 mmol), polystyrene-bound diisopropylamine (0.385 g, loading: 2.0 to 3.5 mmol/g), and CH2Cl2 (10 mL). Shake the mixture overnight at room temperature. Filter the mixture and wash the polystyrene resin with 1:1 CH2Cl2/MeOH. Subject the mixture to flash column chromatography on an ISCO Companion (12 g column, eluting with 10% 2M NH3 in MeOH/CH2Cl2) to yield a colorless oil (0.036 g). Dissolve the oil in CH2Cl2, wash with 1.0M NaOH (3×25 mL), dry over Na2SO4, filter, concentrate in vacuo, and pump overnight on high vacuum to yield the desired product (0.031 g, 40%). mass spectrum (m/e): 509.0 (M+1), 507.0 (M−1). 1H NMR (400 MHz, DMSO-d6) δ 10.28 (s, 1H), 8.03 (d, J=8.8 Hz, 2H), 7.80-7.78 (m, 1H), 7.73-7.71 (m, 1H), 7.61-7.48 (m, 4H), 7.40-7.33 (m, 2H), 3.50 (d, J=8.0 Hz, 1H), 3.13 (s, 3H), 2.65-2.55 (m, 1H), 2.44-2.34 (m, 2H), 2.28-2.21 (m, 1H), 2.23 (s, 3H), 1.93-1.83 (m, 2H), 1.49-1.39 (m, 2H).

Workup

  1. customthe mixture overnight
  2. customat room temperature
  3. filtrationFilter the mixture
  4. washwash the polystyrene resin with 1:1 CH2Cl2/MeOH
  5. washon an ISCO Companion (12 g column, eluting with 10% 2M NH3 in MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-cf9fe9ae45e04e9bba64476a2d518204
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

Loading…