1-Methyl-4-(methylamino)piperidine → Methyl-(1-methyl-piperidin-4-yl)-(5-nitro-benzooxazol-2-yl)-amine

HRID 1174933Notes

Reaction equation

HRID 1174933 reaction equation
C(S[C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:7]=2[N:8]=1)C.[CH3:16][NH:17][CH:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1>>[CH3:16][N:17]([CH:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 5663231-Methyl-4-(methylamino)piperidineHCID 574214952-Ethylsulfanyl-5-nitrobenzooxazole

Product 1

HCID 59558006Methyl-(1-methyl-piperidin-4-yl)-(5-nitro-benzooxazol-2-yl)-amine

Procedure

The title compound is prepared according to the procedure described in General Method A, using 2-ethylsulfanyl-5-nitrobenzooxazole (1.17 g, 5.23 mmol) and methyl-(1-methyl-piperidin-4-yl)-amine (1.37 mL, 9.42 mmol) in anhydrous THP (10 mL) at 100° C.: (0.608 g, 40%). mass spectrum (m/e): 291.0 (M+1).

Workup

  1. customat 100° C.

Sources & evidence

ORD record
ord-15ba5111b4234b948c3f2f233bc5ee49
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

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