HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57771772, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Chloropyrazinoic acid | HCID 465472 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | N2-Methyl-N2-(1-methyl-piperidin-4-yl)-benzooxazole-2,5-diamine | HCID 59558009 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57771772 | HCID 57771772 | — |
Reaction Steps
The title compound was prepared using N2-Methyl-N2-(1-methyl-piperidin-4-yl)-benzooxazole-2,5-diamine (0.368 g, 1.41 mmol), 5-Chloro-pyrazine-2-carboxylic acid (0.247 g, 1.55 mmol), HATU (0.645 g, 1.70 mmol), and DMAP (0.016 g, 0.141 mmol) in CH3CN (20 mL). The compound was subjected to flash column chromatography (120 g column, 2-8% 2N NH3 in MeOH/CH2Cl2) to yield an impure mixture, which was carried on to the next reaction (0.316 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838543B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-a9357520c4a9459ca7770a6eaaac6cd8 |
| Source note | uspto-grants-2010_11 |