Hydrochloric Acid → HCID 57771683, compound

Participants

Reaction Steps

Suspend 7-methyl-6-nitro-benzothiazol-2-ylamine (5.17 g, 24.7 mmol) in conc. HCl (70 mL) and water (70 mL). Add copper (1) chloride (542 mg, 5.47 mmol) followed by slow addition of sodium nitrite (17.4 g, 252 mmol). Stir at rt for 2 h and then add water (100 mL). Filter the solid and dry in a vacuum oven at 40° C. overnight to yield 4.45 g (79%) of the title compound: 1H NMR δH (400 MHz, DMSO) 8.16 (d, J=9.2 Hz, 1H), 8.01 (d, J=8.8 Hz, 1H), 2.71 (s, 3H).

Provenance & Evidence