反应详情

A solution of 2-methyl-biphenyl-4-carboxylic acid methyl ester (0.10 g, 0.44 mmol) in CH3OH (5 mL) and H2O (0.5 mL) is reacted with NaOH (88 mg, 2.2 mmol) at reflux for 2 h. Organic solvent is removed in vacuo, the residue is diluted with H2O, and extracted with Et2O. The aqueous layer is acidified with 5 M HCl, extracted with Et2O, dried with MgSO4, filtered and concentrated to give the title compound as a white solid (72 mg, 77%).

1. temperatureat reflux for 2 h
2. customOrganic solvent is removed in vacuo
3. additionthe residue is diluted with H2O
4. extractionextracted with Et2O
5. extractionextracted with Et2O
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. concentrationconcentrated