4-(Cyclohexylmethoxy)benzoic acid → HCID 11576353, compound

HRID 1174979Notes

Reaction equation

HRID 1174979 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:18][N:19]([CH3:34])[CH2:20][CH2:21][N:22]([CH3:33])[C:23]1[S:24][C:25]2[CH:31]=[C:30]([NH2:32])[CH:29]=[CH:28][C:26]=2[N:27]=1>>[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:32][C:30]3[CH:29]=[CH:28][C:26]4[N:27]=[C:23]([N:22]([CH2:21][CH2:20][N:19]([CH3:18])[CH3:34])[CH3:33])[S:24][C:25]=4[CH:31]=3)=[O:15])=[CH:16][CH:17]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 250196894-(Cyclohexylmethoxy)benzoic acidHCID 55226563N2-(2-Dimethylamino-ethyl)-N2-methyl-benzothiazole-2,6-diamine

Product 1

HCID 11576353HCID 11576353, compound

Procedure

The title compound is prepared by following Method A, using 4-cyclohexylmethoxy-benzoic acid (Crooks, S. L.; Merrill, B. A.; Wightman, P. D. WO 9603983 A1.) (0.20 g, 0.86 mmol), and N*2*-(2-dimethylamino-ethyl)-N*2*-methyl-benzothiazole-2,6-diamine (0.17 g, 0.68 mmol) to afford 0.12 g (38%). LC/MS: Retention time=5.67 min; (m/z): calcd for C26H34N4O2S (M+H)+: 467.7; found: 467.0.

Workup

  1. customto afford 0.12 g (38%)

Sources & evidence

ORD record
ord-fc7b26a5fcdc4f758310e150c4cfa58d
Source dataset
uspto-grants-2010_11
Patent number
US07838543B2

Reaction notes

Loading…