2'-Chloro-4'-ethoxy[1,1'-biphenyl]-4-carboxylic acid → HCID 57771710, compound

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Reaction Steps

The title compound is prepared by following Method A, using 2′-chloro-4′-ethoxy-biphenyl-4-carboxylic acid (0.48 g, 1.73 mmol), and N*2*-(2-dimethylamino-ethyl)-N*2*-methyl-benzothiazole-2,6-diamine (0.33 g, 1.33 mmol) to afford 2′-chloro-4′-ethoxy-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-amide (0.48 g, 71%). The material is dissolved in EtOH and treated with 1.0 M HCl in EtOH (0.94 mL). Organic solvent is removed in vacuo, the residue is dissolved in i-PrOH, heptane is added and the resulting precipitate is collected to give 0.43 g (84%) of the hydrochloride salt. LC/MS: Retention time=5.51 min; (m/z): calcd for C27H29ClN4O2S (M+H)+: 510.1; found: 510.0.

Provenance & Evidence