N2-(2-Dimethylamino-ethyl)-N2-methyl-benzothiazole-2,6-diamine → HCID 57771724, compound

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Reaction Steps

The title compound is prepared by following Method A, using 2′-chloro-4′-isopropoxy-biphenyl-4-carboxylic acid (0.35 g, 1.21 mmol), and N*2*-(2-dimethylamino-ethyl)-N*2*-methyl-benzothiazole-2,6-diamine (0.23 g, 0.93 mmol) to afford 2′-chloro-4′-isopropoxy-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-amide (0.23 g, 48%). The material is dissolved in EtOH and treated with 1.0 M HCl in EtOH (0.44 mL). Organic solvent is removed in vacuo, the residue is dissolved in i-PrOH, heptane is added and the resulting precipitate is collected to give 0.24 g (96%) of the hydrochloride salt. LC/MS, Retention time=5.73 min; (m/z): calcd for C28H31ClN4O2S: 523.1; found: 523.0.

Provenance & Evidence