N2-(2-Dimethylamino-ethyl)-N2-methyl-benzothiazole-2,6-diamine → HCID 11656851, compound

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Reaction Steps

The title compound is prepared by following Method A, using 2′-chloro-4′-trifluoromethoxy-biphenyl-4-carboxylic acid (0.057 g, 0.18 mmol), and N*2*-(2-Dimethylamino-ethyl)-N*2*-methyl-benzothiazole-2,6-diamine (0.38 g, 0.15 mmol) to afford 2′-chloro-4′-trifluoromethoxy-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-amide (0.033 g, 40%). The material is dissolved in EtOH and treated with 1.0 M HCl in EtOH (0.06 mL). Heptane is added and the resulting precipitate is collected to give 0.028 g (78%) of the hydrochloride salt. LC/MS, Retention time=5.38 nm; (m/z): calcd for C26H24ClF3N4O2S (M+H)+: 549.0; found: 549.0.

Provenance & Evidence