(4-Fluoro-2-methylphenyl)boronic acid → 4'-Fluoro-2'-methyl-biphenyl-4-carboxylic acid {2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-amide

Participants

Reaction Steps

The title compound is prepared by following a procedure analogous to Example 113, Step 1, using N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-benzothiazol-6-yl}-4-iodo-benzamide (0.15 g, 0.31 mmol) and 4-fluoro-2-methyl-phenyl boronic acid (0.071 g, 0.38 mmol) to afford 0.084 g (59%). LC/MS, Retention time=4.79 min; (m/z): calcd for C26H27FN4OS (M+H)+: 463.6; found: 463.0.

Provenance & Evidence