2,2-Dimethyl-3,4-epoxy-6-cyanochroman → HCID 68644297, compound

HRID 1175017Notes

Reaction equation

HRID 1175017 reaction equation
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[CH:4]2[O:14][CH:3]12.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH:27]=[CH:26][C:25](=[O:28])[NH:24]2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]2[CH:27]=[CH:26][C:25]([O:28][CH:4]3[C:5]4[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=4)[O:11][C:2]([CH3:1])([CH3:15])[CH:3]3[OH:14])=[N:24]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 113560261-(4-Chlorophenyl)-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 68644297HCID 68644297, compound

Procedure

Following the procedure in Example 1, using (±)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and 1-(4-chloro-phenyl)-1,2-dihydro-pyrazol-3-one as starting materials, the title compounds were prepared as white solids.

Sources & evidence

ORD record
ord-44e7e46584d44da1ae632bddf97612da
Source dataset
uspto-grants-2010_11
Patent number
US07838553B2

Reaction notes

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