4-Amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile → HCID 178431181, compound

Participants

Reaction Steps

4-Amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile (5 mmoL) and 6-chloro-2-methoxy-1H-quinazolin-4-one (5 mmoL) in toluene (15 mL) in a sealed tube were heated at 150° C. for 4 hrs. The solvent was removed and the residue was purified by silica gel chromatography with hexanes and ethyl acetate to yield the title compound as white solid.

Provenance & Evidence