Trifluoroacetic acid → HCID 67415388, compound

Participants

Reaction Steps

Trifluoroacetic acid (50 mL) was added to a solution of tert-butyl 4-({4-[(3-chloro-2-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}oxy)piperidine-1-carboxylate (750 m g, 1.49 mmol) in methylene chloride (1 mL) and Triethylsilane (1 mL) and the solution stirred for 1 hour. The reaction mixture was then evaporated under reduced pressure and the residues re-dissolved in EtOAc (5 mL). This solution was then treated with 1M HCl/Diethylether (1 mL) followed by more Diethylether (50 mL) to give a heavy white precipitation. The resulting solids were collected following centrifugation and dried under vacuum to give N-(3-chloro-2-fluorophenyl)-6-methoxy-7-(piperidin-4-yloxy)quinazolin-4-amine dihydrochloride 5 as an white solid (750 mg); 1H NMR Spectrum: (DMSO-d6): 2.00-2.20 (m, 2H), 2.25-2.45 (m, 2H), 3.15-3.50 (m, 4H), 4.15 (s, 3H), 5.02 (m, 1H), 7.48 (m, 1H), 7.60-7.85 m, 3H), 8.35 (s, 1H), 8.85 (s, 1H), 9.56 (bs, 2H); Mass Spectrum: (M+H)+ 403.08.

Provenance & Evidence