Ethyl orthoformate → HCID 11529091, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-bromo-3-hydrazino-1,2,4-benzotriazine 1-oxide (1 g, 3.91 mmol) and 1,1,1-triethoxymethane (6.24 g, 42.08 mmol) was heated to 145° C. for 3 h, and the ethanol formed during the reaction was continuously distilled off. After cooling in a refrigerator for 12 h, the solid filtered off and washed with ether to give 7-bromo[1,2,4]triazolo[3,4-c][1,2,4]benzotriazine-5-oxide, (Compound Number 5, 0.68 g, 63% yield), 1H-NMR (300 MHz; DMSO): 9.95 ppm (s,1H, H-1); 8.60 ppm (d,1H, H-6); 8.47 ppm (d, 1H, H-9) and 8.38 ppm (dd,1H, H-8).

Provenance & Evidence