Acetic Anhydride → HCID 68771244, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-amino-N-{(1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}cyclopropane-carboxamide hydrochloride (0.50 g, 1.30 mmol) in DMF (5.0 mL) was added acetic anhydride (0.15 g, 1.43 mmol). The reaction mixture was cooled to 0° C., and DIEA (0.34 g, 2.6 mmol) was added slowly over 1 h. The reaction was allowed to stir at 0° C. After 1.5 h, the reaction mixture was diluted with H2O (20 mL) and washed with EtOAc (2×30 mL). The organic layers were combined and washed with H2O (2×20 mL), dried over MgSO4, filtered, and concentrated to give the title compound (0.473 g, 93%). LC/MS: Rt=1.78 min, ES+391 (Formic Acid method).

Provenance & Evidence