HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Ether → 3-Methoxy-4-(2-methoxyethoxy)phenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Ether | HCID 8254 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734650 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | MTBE heptane | HCID 22389680 | — |
| Product | 3-Methoxy-4-(2-methoxyethoxy)phenylboronic acid | HCID 66683993 | — |
Reaction Steps
4-Hydroxy-3-methoxyphenylboronic acid pinacol ester (Aldrich, 518786) (1 g; 4 mmol), 2-bromomethyl)-methylether (0.83 g; 6 mmol) and Cs2CO3 (2.6 g; 8 mmol) in DMF (10 ml) are heated to 130° C. for 45 minutes. The reaction mixture is diluted with TBME/heptane (5 ml/5 ml), filtered and evaporated to deliver the title compound as yellow oil used without further purification in Example 79.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07838674B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-2162e5bd9a1b4cfdad86ae80be1b76d2 |
| Source note | uspto-grants-2010_11 |